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Apple Silicon (M1/M2/M3) Macs run a native arm64 CPU architecture, while Intel Macs run x86_64. Permission Error on Apple Silicon often traces to pre-built binaries that are x86_64-only and require Rosetta 2 emulation — or fail entirely without it. Pre-built binaries downloaded as releases (not compiled from source) may not include an arm64 slice. Check the architecture of any binary with file /path/to/binary — it shows whether it is arm64, x86_64, or universal. Native Node.js modules compiled for x86_64 need to be recompiled for arm64: run npm rebuild after switching Node.js architecture. Homebrew on Apple Silicon installs to /opt/homebrew (not /usr/local as on Intel), so scripts that hard-code /usr/local/bin paths fail silently. Tools installed via Rosetta (x86_64 Homebrew) and native arm64 Homebrew can coexist but manage separate package sets — verify which Homebrew is active with which brew and brew --prefix. Docker on Apple Silicon runs Linux containers in an arm64 VM — see Docker's platform compatibility section for details on x86_64 image emulation.